Contribution of sarcomere gene mutations to left atrial function in patients with hypertrophic cardiomyopathy

Chung, Hyemoon; Kim, Yoonjung; Park, Chul Hwan; Kim, In-Soo; Kim, Jong-Youn; Min, Pil-Ki; Yoon, Young Won; Kim, Tae Hoon; Lee, Byoung Kwon; Hong, Bum-Kee; Rim, Se-Joong; Kwon, Hyuck Moon; Lee, Kyung-A; Choi, Eui-Young

doi:10.1186/s12947-020-00233-y

Cardiovascular Ultrasound

Table 2 Univariate and multivariate analysis for a’ velocity

From: Contribution of sarcomere gene mutations to left atrial function in patients with hypertrophic cardiomyopathy

	a’				LA dysfunction (a’ < 6 cm/s)
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	(r)	(p)	(β)	(p)	OR (95% CI)	p	OR (95% CI)	p
Age, per year	0.102	0.166			0.98 (0.95–1.01)	0.098
Dynamic obstruction	−0.069	0.348			3.68 (1.60–8.45)	0.002
ApHCM	0.182	0.013	0.057	0.341	0.38 (0.16–0.90)	0.029	1.34 (0.39–4.57)	0.638
LVEF-by echo, per %	0.030	0.683			0.93 (0.88–0.99)	0.015
E, per cm/s	−0.260	< 0.001			26.39 (3.40–204.94)	0.002
A, per cm/s	0.291	< 0.001			0.06 (0.006–0.49)	0.009
e’, per 100 cm/s	0.232	0.001			0.74 (0.57–0.97)	0.030
E/e’	0.411	< 0.001	−0.089	0.190	1.17 (1.08–1.25)	< 0.001	1.07 (0.97–1.17)	0.182
s’, per 100 cm/s	0.592	< 0.001	0.484	< 0.001	0.47 (0.34–0.65)	< 0.001	0.52 (0.34–0.78)	0.001
LA volume index, per mL/m²	−0.418	< 0.001	− 0.200	0.002	1.05 (1.03–1.07)	< 0.001	1.04 (1.01–1.07)	0.004
Presence of sarcomere mutations	0.211	0.004	−0.138	0.017	4.76 (2.05–11.02)	< 0.001	5.33 (1.71–16.61)	0.004
LV mass index by CMR (n = 135)	−0.214	0.021			1.02 (1.00–1.05)	0.046
Presence of LGE (n = 133)	−0.248	0.007			1.89 (0.49–7.21)	0.353
No of LGE segment (n = 133)	−0.334	< 0.001			1.26 (1.07–1.49)	0.006
%LGE mass (n = 133)	−0.132	0.156			1.03 (0.97–1.09)	0.312
LV myocardial GLS (n = 135)	−0.045	0.627			1.05 (0.93–1.18)	0.435
LA GLS (n = 135), per %	0.076	0.413			0.92 (0.85–0.99)	0.034
LA minimal volume (n = 135), per mL	−0.443	< 0.001			1.03 (1.02–1.05)	< 0.001
LA maximal volume (n = 135), per mL	−0.427	< 0.001			1.02 (1.01–1.04)	0.001
LA total emptying fraction (n = 135), per %	0.251	0.006			0.93 (0.89–0.97)	0.001
LA active emptying fraction (n = 119), per %	0.248	0.006			0.93 (0.88–0.97)	0.003
5-yr-SCD risk (n = 123)	−0.314	0.001			1.45 (1.06–1.99)	0.020
Presence of NSVT (n = 123)	−0.214	0.036			5.27 (1.58–17.66)	0.007

Abbreviations are same as in Table 1

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