Skip to main content

Table 4 Structural predictors of sub-optimal MitraClip response

From: Transcatheter MitraClip repair alters mitral annular geometry – device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response

 

Odds Ratio (95% Confidence Interval)

p

AUC

Cutoffb

Sensitivity

Specificity

3D Transesophogeal Echo

 Mitral Annular Area (cm2/m2)

1.93 (1.22–3.06)

0.005

0.72 (0.59–0.84)

6.72

82%

46%

 Annular Circumference (cm/m2)

1.96 (1.12–3.41)

0.02

0.65 (0.52–0.79)

6.83

82%

42%

 Antero-Posterior Diameter (cm)

7.16 (1.72–29.85)

0.007

0.72 (0.60–0.85)

3.77

80%

54%

 Anterolateral-Posteromedial Diameter (cm)

6.35 (1.58–25.44)

0.009

0.70 (0.57–0.82)

4.03

87%

38%

 Annular Height (cm)

8.27 (0.73–93.28)

0.09

0.63 (0.50–0.77)

0.62

82%

35%

 Tenting Volume (cm3)

1.26 (0.93–1.70)

0.14

0.64 (0.50–0.78)

2.69

82%

38%

 Tenting Area (cm2)

1.70 (0.85–3.38)

0.13

0.63 (0.49–0.77)

1.51

80%

38%

 Tenting Height (mm)

1.17 (0.98–1.40)

0.09

0.64 (0.50–0.79)

7.80

87%

50%

 Anterior Leaflet Angle (°)

0.99 (0.96–1.03)

0.67

0.50 (0.35–0.64)

24.55

82%

27%

 Posterior Leaflet Angle (°)

1.06 (0.99–1.15)

0.11

0.64 (0.50–0.79)

16.05

85%

46%

 Nonplanar Angle (°)

0.97 (0.93–1.01)

0.17

0.40 (0.26–0.54)

140.40

82%

11%

2D Transthoracic Echo

 Mitral Annular Diameter (cm/m2)

6.50 (1.27–33.20)

0.02

0.64 (0.51–0.76)

1.67

81%

46%

 LV End-diastolic volume (ml/m2)a

1.25 (1.04–1.50)

0.01

0.67 (0.55–0.79)

8.46

81%

39%

 LA Volume (ml/m2)a

1.22 (1.03–1.44)

0.02

0.68 (0.56–0.80)

5.41

83%

54%

 LA 2-Chamber area (cm2)

1.06 (1.00–1.11)

0.04

0.64 (0.52–0.77)

24.65

87%

33%

 LA 4-Chamber area (cm2)

1.09 (1.02–1.16)

0.006

0.68 (0.56–0.80)

27.95

81%

54%

  1. aper 10 ml increment
  2. bcutoffs chosen for maximum specificity with minimum sensitivity ≥80%
  3. Data in bold are significant