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Table 2 Comparison of patients’ data between patients HFpEF and HFrEF

From: Different determinants of exercise capacity in HFpEF compared to HFrEF

Variable

HFpEF

HFrEF

P value

 

(n = 55)

(n = 56)

 

Clinical and biochemical data

 Age (years)

63 ± 6.8

62 ± 12

0.767

 Body-mass index (kg/m2)

29 ± 4

28 ± 3.6

0.130

 Waist/hips ratio

0.96 ± 0.06

0.96 ± 0.06

0.996

 Fasting glucose (mmol/L)

7.1 ± 3.1

6.7 ± 2.3

0.462

 Total cholesterol (mmol/L)

5.1 ± 1.1

4.7 ± 1.1

0.054

 Triglycerides (mmol/L)

1.8 ± 0.7

1.5 ± 0.7

0.137

 Creatinine (μmol/L)

87 ± 16

105 ± 63

0.052

 Hemoglobin (g/dL)

12.8 ± 1.9

12.4 ± 1.5

0.078

 Baseline heart rate (beats/min)

70 ± 15

79 ± 15

0.005

 NT-ProBNP (pg/mL)

681 ± 1280

1665 ± 1801

0.001

 6-min walk distance (m)

339 ± 106

282 ± 119

0.010

 PPV of 6-min walk distance (%)

56 ± 19

45 ± 20

0.004

Echocardiographic data

 IVSd (cm)

1.1 ± 0.1

1.1 ± 0.2

0.666

 Left atrium (cm)

4.2 ± 0.8

4.6 ± 0.7

0.004

 LV EDD (cm)

5.2 ± 0.7

6.3 ± 0.9

<0.001

 LV ESD (cm)

3.5 ± 0.7

5.1 ± 1

<0.001

 EDV (ml)

135 ± 44

213 ± 67

<0.001

 ESV (ml)

56 ± 8.7

140 ± 52

<0.001

 LV EF (%)

59.6 ± 8.7

35 ± 7.5

<0.001

 Lateral MAPSE (cm)

1.27 ± 0.3

1.02 ± 0.4

0.001

 Septal MAPSE (cm)

1.14 ± 0.2

0.85 ± 0.2

<0.001

 TAPSE (cm)

2.3 ± 0.4

2.1 ± 0.5

0.062

 LVPWd (cm)

1.05 ± 0.2

1.06 ± 0.2

0.688

 E/A ratio

0.81 ± 0.3

1.3 ± 0.9

0.001

 LVM (g)

224 ± 69

310 ± 77

<0.001

 LVMI (g/m2.7)

50 ± 16

67 ± 23

<0.001

 E wave DT

189 ± 44

159 ± 49

0.002

 Filling time (ms)

454 ± 147

372 ± 99

0.001

 IVRT (ms)

122 ± 39

130 ± 43

0.407

 PA acceleration time (ms)

118 ± 20

101 ± 23

<0.001

 E/e’ ratio

9.4 ± 4.7

13.5 ± 6.4

0.001

 Lateral e’ (cm/s)

6.7 ± 2.6

5.3 ± 2.2

0.009

 Lateral a’ (cm/s)

8.6 ± 3.3

7.1 ± 3.8

0.051

 Lateral s’ (cm/s)

5.7 ± 1.3

4.8 ± 1.7

0.006

 Septal e’ (cm/s)

5.7 ± 2.5

4.0 ± 1.1

<0.001

 Septal a’ (cm/s)

7.9 ± 2.1

6.2 ± 2.0

<0.001

 Septal s’ (cm/s)

4.9 ± 1.6

3.8 ± 0.9

<0.001

 Right e’ (cm/s)

9.4 ± 3.2

7.9 ± 2.4

0.012

 Right a’ (cm/s)

12.7 ± 4.5

12.2 ± 4.2

0.593

 Right s’ (cm/s)

9.1 ± 3.1

8.3 ± 2.7

0.187

LAV max

62 ± 23

83 ± 57

0.005

LAV min

29 ± 18

51 ± 34

<0.001

 LA EF (%)

53 ± 15

43 ± 18

0.012

  1. LV left ventricle, EDD end-diastolic dimension, ESD end-systolic dimension, DT deceleration time, FT filling time, ET Ejection time, HR heart rate, IVSd interventricular septum in diastole, LVPWd left ventricular posterior wall in diastole, MAPSE mitral annular plane systolic excursion, TAPSE tricuspid annular plane systolic excursion, PA pulmonary artery, A atrial diastolic velocity, E early diastolic filling velocity, e’ early diastolic myocardial velocity, s’ systolic myocardial velocity, LA left atrial, LAV max left atrial maximal volume, LAV min left atrial minimal volume, LA EF left atrial eemptying fraction, LVM left ventricular mass, LVMI left ventricular mass index, PPV percentage of the predicted value