LA severity partition cut-off | ||||||||
---|---|---|---|---|---|---|---|---|
LA enlargement (LAVi > 34 ml/m2) | Mild LA enlargement | Moderate LA enlargement | Severe LA enlargement | |||||
MACCEs | HR (95 % CI) | p | HR (95 % CI) | p | HR (95 % CI) | p | HR (95 % CI) | p |
All Patients | 2.1 (1.4–3.1) | 0.000# | 1.2 (0.7–2.2) | 0.457 | 2.2 (1.3–2.7) | 0.003* | 3.1 (2.0–4.9) | 0.000# |
CABG Patients | 2.1 (1.3–3.2) | 0.001* | 1.8 (0.7–4.5) | 0.201 | 3.2 (1.2–7.9) | 0.013* | 6.1 (2.6–14.1) | 0.000# |
Valve Patients | 2.7 (1.2–6.0) | 0.011* | 1.6 (0.5–4.9) | 0.402 | 2.9 (1.1–7.7) | 0.025* | 3.3 (1.4–8.0) | 0.005# |
Aortic stenosis | 6.6 (0.8–51) | 0.071 | 0.1 (0.1–1.0) | 0.521 | 1.9 (0.3–11) | 0.482 | 1.6 (0.2–9.6) | 0.060 |
Aortic regurgitation | 4.2 (1.5–11) | 0.004* | 3.3 (0.7–15) | 0.117 | 3.7 (1.1–12) | 0.028* | 4.5 (1.5–13) | 0.006* |
Mitral regurgitaton | 4.2 (1.5–11) | 0.004* | 1.9 (0.1–31) | 0.638 | 6.4 (0.7–57) | 0.096 | 7.0 (0.9–57) | 0.067 |
Valve + CABG | 2.3 (0.9–5.6) | 0.053 | 1.6 (0.4–6.3) | 0.484 | 2.4 (0.7–7.8) | 0.122 | 2.6 (0.9–7.1) | 0.050 |
All-cause mortality | 1.6 (0.9–2.8) | 0.064 | 1.2 (0.5–2.7) | 0.533 | 1.6 (0.7–3.5) | 0.258 | 2.2 (1.1–4.2) | 0.025* |
CV mortality | 2.2 (1.0–4.5) | 0.032* | 1.2 (0.4–3.7) | 0.739 | 2.5 (0.9–6.6) | 0.070 | 3.1 (1.3–7.4) | 0.010* |
Heart failure | 1.8 (0.9–3.5) | 0.057 | 0.8 (0.2–2.5) | 0.796 | 2.5 (1.0–5.8) | 0.034* | 2.5 (1.1–5.4) | 0.023* |
Stroke | 1.6 (0.5–4.8) | 0.327 | 1.0 (0.2–5.3) | 0.918 | n.a. | n.a. | 3.8 (1.2–11.9) | 0.019* |
n.a. | ||||||||
ACS | 1.9 (0.8–4.4) | 0.137 | 1.5 (0.4–4.9) | 0.492 | 1.6 (0.4–5.9) | 0.483 | 2.6 (0.9–7.4) | 0.067 |